The use of continuous brain parenchymal impedance dispersion to measure glymphatic function in humans

Paul Dagum, Laurent Giovangrandi, Swati Rane Levendovszky, Jake J Winebaum, Tarandeep Singh, Yeilim Cho, Robert M Kaplan, Michael S Jaffe, Miranda M Lim, Carla Vandeweerd, Jeffrey J Iliff

medRxiv 2024

Preliminary cross-sectional investigations into the human glymphatic system using multiple novel non-contrast MRI methods

Swati Rane Levendovszky, Jacqueline Flores, Elaine Peskind, Lena Vaclavu, Matthias van Osch, Jeffrey Iliff

bioRxiv 2023

Sleep Dependent Changes of Lactate Concentration in Human Brain

Selda Yildiz, Miranda M. Lim, Manoj K. Sammi, Katherine Powers, Charles F. Murchison, Jeffrey J. Iliff, William D. Rooney

bioRxiv 2021

Interrogation of dynamic glucose-enhanced MRI and fluorescence-based imaging reveals a perturbed glymphatic network in Huntington’s disease

Hongshuai Liu, Lin Chen, Chuangchuang Zhang, Chang Liu, Yuguo Li, Liam Cheng, Zhiliang Wei, Ziqin Zhang, Hanzhang Lu, Peter CM van Zijl, Jeffrey J Iliff, Jiadi Xu, Wenzhen Duan

BioRXiv 2023

The Impact of Anesthesia on Ultrasonic Glymphatic Perturbation Protocol: Alertness, and Glymphatic Influx

Haijun Xiao, Binita Shrestha, Alexander Aviles Cruz, Jeffrey Iliff, Tyrone Porter, Muna Aryal

bioRxiv 2024

Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinal Fluid Compartment

Deidre J Jansson, Jeffrey J Iliff

Neuraxial Therapeutics: A Comprehensive Guide

Perivascular space burden and cerebrospinal fluid biomarkers in US Veterans with blast-related mild traumatic brain injury

Erin A Yamamoto, Seiji Koike, Madison Luther, Laura Dennis, Miranda M Lim, Murray Raskind, Kathleen Pagulayan, Jeffrey Iliff, Elaine Peskind, Juan A Piantino

Journal of Neurotrauma 2024

Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project

Suzan van Amerongen, Surya V Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D Cherry, Charles Bernick, Yonas E Geda, Jennifer V Wethe, Douglas I Katz, Michael L Alosco, Charles H Adler, Laura J Balcer, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H Daneshvar, Elizabeth A Colasurdo, Jeffrey J Iliff, Gail Li, Elaine R Peskind, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern

Journal of Neuroinflammation 2024

Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system.

Ester Licastro, Giuseppe Pignataro, Jeffrey J Iliff, Yanxiao Xiang, Eng H Lo, Kazuhide Hayakawa, Elga Esposito

Communications Biology 2024

Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino

Microgravity 2024

CSF β-amyloid and tau biomarker changes in Veterans with mild traumatic brain injury.

Ge Li, Jeffrey Iliff, Jane Shofer, Cynthia L Mayer, James Meabon, David Cook, Kathleen F Pagulayan, Murray A Raskind, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind

Neurology 2024

Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults

Samantha A Keil, Abigail Schindler, Marie X Wang, Juan Piantino, Lisa C Silbert, Jonathan E Elliott, Madeleine Werhane, Ronald Thomas, Sherry Willis, Miranda Lim, Jeffrey Iliff

JAMA Network Open 2023

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

Aguilar-Calvo P , Malik A , Sandoval DR , Barback C , Orrù CD , Standke HG , Thomas O , Dwyer CA , Pizzo DP , Bapat J , Soldau K , Ogawa R , Riley MB , Nilsson KPR , Kraus A , Caughey B , Iliff JJ , Vera D , Esko JD , Sigurdson CJ

PLOS Pathology 2023

A case of prazosin in treatment of rapid eye movement sleep behavior disorder

Yeilim Cho, Jeffrey Iliff, Miranda Lim, Murray Raskind, Elaine Peskind

Journal of Clinical Sleep Medicine 2023

Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice

Maria Assunta Rocca, Monica Margoni, Marco Battaglini, Arman Eshaghi, Jeffrey Iliff, Elisabetta Pagani, Paolo Preziosa, Loredana Storelli, Toshiaki Taoka, Paola Valsasina, Massimo Filippi

Radiology 2023

The effect of aquaporin-4 mis-localization on Aβ deposition in mice

Taylor J Pedersen, Samantha A Keil, Warren Han, Marie X Wang, Jeffrey J Iliff

Neurobiology of Disease 2023

Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function

Sutton B Richmond, Swati Rane, Moriah R Hanson, Mehmet Albayram, Jeffrey J Iliff, Dawn Kernagis, Jens T Rosenberg, Rachael D Seidler

European Journal of Neuroscience 2023

Reader Response: Association of Sleep, Neuropsychological Performance, and Gray Matter Volume With Glymphatic Function in Community-Dwelling Older Adults

Juan A Piantino, Jeffrey J Iliff, Miranda M Lim, Swati Rane Levendovszky

Neurology 2023

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Dhruv Singhal, Katy Börner, Elliot L Chaikof, Michael Detmar, Maija Hollmén, Jeffrey J Iliff, Maxim Itkin, Taija Makinen, Guillermo Oliver, Timothy P Padera, Ellen M Quardokus, Andrea J Radtke, Hiroo Suami, Griffin M Weber, Ilsa I Rovira, Selen C Muratoglu, Zorina S Galis

Frontiers in Physiology 2023

Locoregional CAR T cells for children with CNS tumors: clinical procedure and catheter safety

Nicholas A Vitanza, Rebecca Ronsley, Michelle Choe, Casey Henson, Mandy Breedt, Adriel Barrios-Anderson, Amy Wein, Christopher Brown, Adam Beebe, Ada Kong, Danielle Kirkey, Brittany M Lee, Sarah ES Leary, Erin E Crotty, Corrine Hoeppner, Susan Holtzclaw, Ashley L Wilson, Joshua A Gustafson, Jessica B Foster, Jeffrey J Iliff, Hannah E Goldstein, Samuel R Browd, Amy Lee, Jeffrey G Ojemann, Navin Pinto, Juliane Gust, Rebecca A Gardner, Michael C Jensen, Jason S Hauptman, Julie R Park

Neoplasia 2023

The glymphatic system: Current understanding and modeling

Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M.

iScience 2022

Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain

Samantha A. Keil, Molly Braun, Ryan O'Boyle, Mathew Sevao, Taylor Pedersen, Sanjana Agarwal, Deidre Jansson, Jeffrey J. Illiff

Neurophotonics 2022

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid beta plaque formation in mice

Matthew Simon, Marie Xun Wang, Ozama Ismail, Molly Braun, Abigail G. Schindler, Jesica Reemmer, Zhongya Wang, Mariya A. Haveliwala, Ryan P. O’Boyle, Warren Y. Han, Natalie Roese, Marjorie Grafe, Randall Woltjer, Detlev Boison, Jeffrey J. Iliff 

Alzheimer’s Research & Therapy 2022

Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight

Kathleen E. Hupfeld, Sutton B. Richmond, Heather R. McGregor, Daniel L. Schwartz, Madison Luther, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Roy F. Riascos, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Lisa Silbert, Jeffrey J. Iliff, Rachael D. Seidler, Juan Piantino

Scientific Reports 2022

Markers of cerebrovascular injury, inflammation, and plasma lipids are associated with Alzheimer’s disease cerebrospinal fluid biomarkers in cognitively normal persons

Deidre Jansson, Marie Wang, Ronald Thomas, Michelle Erickson, Elaine Peskind, Ge Li, Jeffrey Iliff

Journal of Alzheimer’s Disease 2022

Impaired glymphatic function and pulsation alterations in a mouse model of vascular cognitive impairment

Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey Iliff, Karen Horsburgh

Frontiers in Aging Neuroscience 2022

Quantitative analysis of macroscopic solute transport in the murine brain

Lori A Ray, Martin Pike, Mathew Simon, Jeffrey J Iliff, Jeffrey J Heys

Fluid and Barriers of the CNS 2021

Woes with flows under pressure

Deidre J Jansson and Jeffrey J Iliff

Brain Communications 2021

The Bidirectional Link Between Sleep Disturbances and Traumatic Brain Injury Symptoms: A Role for Glymphatic Dysfunction?

Juan A Piantino, Jeffrey J Iliff, Miranda M Lim

Biological Psychiatry 2021

Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis

Mootaz Salman, Philip Kitchen, Andrea Halsey, Marie Wang, Susanna Tornroth-Horsefield, Alex Conner, Jerome Badaut, Jeffrey Iliff, Roslyn Bill

Brain 2021

Aquaporin-4 and glymphatic flow have central roles in brain fluid homeostasis.

Mootaz Salman, Philip Kitchen, Jeffrey Iliff, Roslyn Bill

Nature Reviews Neuroscience 2021

Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity.

Wenri Zhang, Catherine Davis, Douglas Zeppenfeld, Kirsti Golgotiu, Marie Wang, Mariya Haveliwala, Daniel Hong, Yuandong Li, Ruikang Wang, Jeffrey Iliff, Nabil Alkayed.

Journal of Cerebral Blood Flow and Metabolism 2021

Link between mild traumatic brain injury, poor sleep, and MRI-visible perivascular spaces in Veterans.

Juan Piantino, Daniel Schwartz, Madison Luther, Craig Newgard, Lisa Silbert, Murray Raskind, Kathleen Pagulayan, Natalia Kleinhans, Jeffrey Iliff, Elaine Peskind.

Journal of Neurotrauma 2021

Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle.

Marie Xun Wang, Lori Rey, Kenji F. Tanaka, Jeffrey J. Iliff, Jeffrey Heys

Glia 2021

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival

Cymon N Kersch, Cheryl J Claunch, Prakash Ambady, Elmar Bucher, Daniel L Schwartz, Ramon F Barajas Jr, Jeffrey J Iliff, Tyler Risom, Laura Heiser, Leslie L Muldoon, James E Korkola, Joe W Gray, Edward A Neuwelt

Neuro-Oncology Advances 2020

The impact of neurovascular, blood-brain barrier, and glymphatic dysfunction in neurodegenerative and metabolic diseases

Molly Braun and Jeffrey J. Iliff

International Review of Neurobiology 2020

Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges

Shannon Shibata-Germanos, James R. Goodman, Alan Grieg, Chintan A. Trivedi, Bridget C. Benson, Sandrine C. Foti, Ana Faro, Raphael F. P. Castellan, Rosa Maria Correra, Melissa Barber, Christiana Ruhrberg, Roy O. Weller, Tammaryn Lashley, Jeffrey J. Iliff, Thomas A. Hawkins, Jason Rihel

Acta Neuropathologica 2020

Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system

James Goodman and Jeffrey Iliff

Journal of Cerebral Blood Flow and Metabolism 2020

CrossTalk Proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4

Jeffrey Iliff and Matthew Simon

Journal of Physiology 2019

CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent (Smith and Verkman)

Rebuttal from Matthew Simon and Jeffrey Iliff

Rebuttal from Alex J. Smith and Alan S. Verkman

Sleep as a Therapeutic Target in the Aging Brain

Thierno Madjou Bah, James Goodman, Jeffrey J. Iliff

Neurotherapeutics 2019

Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction

Juan Piantino, Miranda M Lim, Craig D. Newgard, Jeffrey J. Iliff

Current Pain and Headache Reports 2019

In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”

Lori Rey, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

Carmen Methner, Anusha Mishra, Kirsti Golgotiu, Yuandong Li, Wei Wei, N. David Yanez, Berislav Zlokovic, Ruikang K. Wang, Nabil J. Alkayed, Sanjiv Kaul, Jeffrey J. Iliff

American Journal of Physiology: Heart and Circulation Physiology 2019

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

Benjamin A. Plog, Nanhong Lou, Clifford A. Pierre, Alex Cove, H. Mark Kenney, Emi Hitomi, Hongyi Kang, Jeffrey J. Iliff, Douglas M. Zeppenfeld, Maiken Nedergaard, G. Edward Vates

Journal of Neurosurgery 2019

Analysis of convective and diffusive transport in the brain interstitium

Lori Ray, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Aquaporin-4-dependent glymphatic solute transport in the rodent brain

Humberto Mestre, Lauren M Hablitz, Anna LR Xavier, Weixi Feng, Wenyan Zou, Tinglin Pu, Hiromu Monai, Giridhar Murlidharan, Ruth M Castellanos Rivera, Matthew J Simon, Martin M Pike, Virginia Plá, Ting Du, Benjamin T Kress, Xiaowen Wang, Benjamin A Plog, Alexander S Thrane, Iben Lundgaard, Yoichiro Abe, Masato Yasui, John H Thomas, Ming Xiao , Hajime Hirase , Aravind Asokan , Jeffrey J Iliff , Maiken Nedergaard

eLife 2018

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Matthew J. Simon, Marie X. Wang, Charles F. Murchison, Natalie E. Roese, Erin L. Boespflug, Randall L. Woltjer, Jeffrey J. Iliff

Scientific Reports 2018

Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease

Erin L. Boespflug, Matthew Simon, Emmalyn Leonard, Marjorie Grafe, Randall Woltjer, Lisa Silbert, Jeffrey Kaye, Jeffrey Iliff

Journal of Alzheimer’s Disease 2018

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects

James R. Goodman, Zachariah O. Adham, Randall L. Woltjer, Amanda W. Lund. Jeffrey J. Iliff

Brain, Behavior and Immunity 2018

The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

Erin Boespflug and Jeffrey Iliff

Biological Psychiatry 2018

The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease

Kevin G. Burfeind, Charles F. Murchison, Shawn K. Westaway, Matthew J. Simon, Deniz Erten-Lyons, Jeffrey A. Kaye, Joseph F. Quinn, Jeffrey J. Iliff

Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017

Neurovascular Unit: Basic and Clinical Imaging with Emphasis on Advantages of Ferumoxytol

Joao Prola Netto, Jeffrey Iliff, Danica Stanimirovic, Kenneth A Krohn, Bronwyn Hamilton, Csanad Varallyay, Seymur Gahramanov, Heike Daldrup-Link, Christopher d’Esterre, Berislav Zlokovic, Haris Sair, Yueh Lee, Saeid Taheri, Rajan Jain, Ashok Panigrahy, Daniel S Reich, Lester R Drewes, Mauricio Castillo, Edward A Neuwelt

Neurosurgery 2018

MR Imaging–based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength

Erin L. Boespflug , Daniel L. Schwartz, David Lahna, Jeffrey Pollock, Jeffrey J. Iliff, Jeffrey A. Kaye, William Rooney, Lisa C. Silbert

Neurology 2018

A transcriptome‐based assessment of the astrocytic dystrophin‐associated complex in the developing human brain

Matthew J. Simon, Charles Murchison, Jeffrey J. Iliff

Journal of Neuroscience Research 2017

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff and Maiken Nedergaard

Journal of Neuroscience 2017

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Douglas M. Zeppenfeld, Matthew Simon, J. Douglas Haswell, Daryl D’Abreo, Charles Murchison, Joseph F. Quinn, Marjorie R. Grafe, Randall L. Woltjer, Jeffrey Kaye, Jeffrey J. Iliff

JAMA Neurology 2017

Methamphetamine induces the release of endothelin

Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West

Journal of Neuroscience Research 2016