preprint papers

Biological sex and BMI influence the longitudinal evolution of adolescent and young adult MRI-visible perivascular spaces

Erin A Yamamoto, Seiji Koike, Caitlyn Wong, Laura Dennis, Madison N Luther, Avery Scatena, Seva Khambadkone, Jeffrey Iliff, Miranda M Lim, Swati Rane Levendovszky, Jonathan Elliott, Giuseppe Barisano, Eva Muller-Oehring, Angelica M Morales, Fiona Baker, Bonnie Nagel, Juan Piantino

bioRxiv 2024.

Aquaporin-4 mis-localization slows glymphatic clearance of α-synuclein and promotes α-synuclein pathology and aggregate propagation.

Molly Braun, Matthew J Simon, Jay Jang, Keith Sanderson, Justyna Swierz, Mathew Sevao, Alexandra B Pincus, Allison J Schaser, Jonathan E Elliott, Miranda M Lim, Vivek K Unni, Abigail G Schindler, C Dirk Keene, Caitlin S Latimer, Jeffrey Iliff

bioRxiv 2024.

The glymphatic system clears amyloid beta and tau from brain to plasma in humans

Jeffrey J. Iliff, Donald L. Elbert, Laurent Giovangrandi, Tarandeep Singh, Venky V. Venkatesh, Alejandro Corbellini, Robert M. Kaplan, Elizabeth Ludington, Kevin Yarasheski, Jeffrey Lowenkron, Carla VandeWeerd, Miranda M. Lim, Paul Dagum

medRXiv 2024

Glymphatic flow resistance in humans measured by multifrequency impedance dispersion

Laurent Giovangrandi, Swati Rane Levendovszky, Jake J Winebaum, Tarandeep Singh, Yeilim Cho, Robert M Kaplan, Michael S Jaffee, Miranda M Lim, Carla Vandeweerd, Jeffrey J Iliff

medRxiv 2024

Sleep Dependent Changes of Lactate Concentration in Human Brain

Selda Yildiz, Miranda M. Lim, Manoj K. Sammi, Katherine Powers, Charles F. Murchison, Jeffrey J. Iliff, William D. Rooney

bioRxiv 2021

The Impact of Anesthesia on Ultrasonic Glymphatic Perturbation Protocol: Alertness, and Glymphatic Influx

Haijun Xiao, Binita Shrestha, Alexander Aviles Cruz, Jeffrey Iliff, Tyrone Porter, Muna Aryal

bioRxiv 2024

published papers

Glymphatic influx and clearance are perturbed in Huntington’s disease

Hongshuai Liu, Lin Chen, Chuangchuang Zhang, Chang Liu, Yuguo Li, Liam Cheng, Yuxiao Ouyang, Catherine Rutledge, John Anderson, Zhiliang Wei, Ziqin Zhang, Hanzhang Lu, Peter CM Van Zijl, Jeffrey J Iliff, Jiadi Xu, Wenzhen Duan

JCI insight 2024.

Repetitive head impacts and perivascular space volume in former american football players

Leonard B Jung, Tim LT Wiegand, Fatima Tuz-Zahra, Yorghos Tripodis, Jeffrey J Iliff, Juan Piantino, Hector Arciniega, Cara L Kim, Lara Pankatz, Sylvain Bouix, Alexander P Lin, Michael L Alosco, Daniel H Daneshvar, Jesse Mez, Farshid Sepehrband, Yogesh Rathi, Ofer Pasternak, Michael J Coleman, Charles H Adler, Charles Bernick, Laura Balcer, Jeffrey L Cummings, Eric M Reiman, Robert A Stern, Martha E Shenton, Inga K Koerte, Yi Su, Kewei Chen, Hillary Protas, Conni Boker, Rhoda Au, Robert C Cantu, Lindsay Farrer, Robert Helm, Neil Kowall, Gustavo Mercier, James Otis, Jason Weller, Irene Simkin, Alondra Andino, Shannon Conneely, Courtney Diamond, Tessa Fagle, Olivia Haller, Tennyson Hung, Nicole Gullotti, Megan Mariani, Brian Mayville, Kathleen McLaughlin, Mary Nanna, Taylor Platt, Sury Pulukuri, Fiona Rica, Madison Sestak, Michael McClean, Douglas Annis, Christine Chaisson, Dianne B Dixon, Carolyn Finney, Kerrin Gallagher, Kaitlin Hartlage, Jun Lu, Brett Martin, Emmanuel Ojo, Joseph N Palmisano, Brittany Pine, Janani Ramachandran, Jennifer Fitzsimmons, Elena M Bonke, Katherine Breedlove, Eduardo Coello, Hujiun Liao, Elizabeth Rizzoni, Vivian Schultz, Annelise Silva, Brynn Vessey, Sarah Banks, Jason Miller, Aaron Ritter, Raelynn de la Cruz, Jan Durant, Moragn Golceker, Nicolette Harmon, Kaeson Kaylegian, Rachelle Long, Christin Nance, Priscilla Sandoval, Robert W Turner, Kenneth L Marek, Andrew Serrano, David W Dodick, Yonas Geda, Jennifer V Wethe, Bryce Falk, Amy Duffy, Marci Howard, Michelle Montague, Thomas Osgood, Debra Babcock, William Barr, Judith Goldberg, Thomas Wisniewski, Ivian Kirov, Yvonne Lui, Charles Marmar, Lisene Hasanaj, Liliana Serrano, Alhassan Al-Kharafi, Allan George, Sammie Martin, Edward Riley, William Runge, Elaine R Peskind, Elizabeth Colasurdo, Daniel S Marcus, Jenny Gurney, Keith A Johnson, Richard Greenwald

JAMA Network Open 2024.

Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function

Molly Braun, Mathew Sevao, Samantha A Keil, Elizabeth Gino, Marie X Wang, Janet Lee, Mariya A Haveliwala, Emily Klein, Sanjana Agarwal, Taylor Pedersen, C Harker Rhodes, Deidre Jansson, David Cook, Elaine Peskind, Daniel P Perl, Juan Piantino, Abigail G Schindler, Jeffrey J Iliff

Brain 2024

A new path to migraine

Andrew Russo and Jeffrey Iliff

Science 2024

Preliminary investigations into human neurofluid transport using multiple novel non-contrast MRI methods

Swati Rane Levendovszky, Jacqueline Flores, Elaine Peskind, Lena Vaclavu, Matthias van Osch, Jeffrey Iliff

Journal of Cerebral Blood Flow and Metabolism 2024

Is CAA a perivascular brain clearance disease? A discussion of the evidence to date and outlook for future studies

Susanne J. van Veluw, Helene Benveniste, Erik N. T. P. Bakker, Roxana O. Carare ,Steven M. Greenberg ,Jeffrey J. Iliff, Sylvie Lorthois, William E. Van Nostrand, Gabor C. Petzold, Andy Y. Shih, Matthias J. P. van Osch 

Cellular and Molecular Life Sciences 2024

Emerging Insights into the Interstitial Distribution of Neuraxial Therapeutics via the Cerebrospinal Fluid Compartment

Deidre J Jansson, Jeffrey J Iliff

Neuraxial Therapeutics: A Comprehensive Guide 2024

Perivascular space burden and cerebrospinal fluid biomarkers in US Veterans with blast-related mild traumatic brain injury

Erin A Yamamoto, Seiji Koike, Madison Luther, Laura Dennis, Miranda M Lim, Murray Raskind, Kathleen Pagulayan, Jeffrey Iliff, Elaine Peskind, Juan A Piantino

Journal of Neurotrauma 2024

Inflammatory biomarkers for neurobehavioral dysregulation in former American football players: findings from the DIAGNOSE CTE Research Project

Suzan van Amerongen, Surya V Pulukuri, Fatima Tuz-Zahra, Yorghos Tripodis, Jonathan D Cherry, Charles Bernick, Yonas E Geda, Jennifer V Wethe, Douglas I Katz, Michael L Alosco, Charles H Adler, Laura J Balcer, Nicholas J Ashton, Kaj Blennow, Henrik Zetterberg, Daniel H Daneshvar, Elizabeth A Colasurdo, Jeffrey J Iliff, Gail Li, Elaine R Peskind, Martha E Shenton, Eric M Reiman, Jeffrey L Cummings, Robert A Stern

Journal of Neuroinflammation 2024

Glymphatic and lymphatic communication with systemic responses during physiological and pathological conditions in the central nervous system.

Ester Licastro, Giuseppe Pignataro, Jeffrey J Iliff, Yanxiao Xiang, Eng H Lo, Kazuhide Hayakawa, Elga Esposito

Communications Biology 2024

Dynamic changes in perivascular space morphology predict signs of spaceflight-associated neuro-ocular syndrome in bed rest.

Sutton B Richmond, Rachael D Seidler, Jeffrey J Iliff, Daniel L Schwartz, Madison Luther, Lisa C Silbert, Scott J Wood, Jacob J Bloomberg, Edwin Mulder, Jessica K Lee, Alberto De Luca, Juan Piantino

Microgravity 2024

CSF β-amyloid and tau biomarker changes in Veterans with mild traumatic brain injury.

Ge Li, Jeffrey Iliff, Jane Shofer, Cynthia L Mayer, James Meabon, David Cook, Kathleen F Pagulayan, Murray A Raskind, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind

Neurology 2024

Longitudinal Sleep Patterns and Cognitive Impairment in Older Adults

Samantha A Keil, Abigail Schindler, Marie X Wang, Juan Piantino, Lisa C Silbert, Jonathan E Elliott, Madeleine Werhane, Ronald Thomas, Sherry Willis, Miranda Lim, Jeffrey Iliff

JAMA Network Open 2023

Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection

Aguilar-Calvo P , Malik A , Sandoval DR , Barback C , Orrù CD , Standke HG , Thomas O , Dwyer CA , Pizzo DP , Bapat J , Soldau K , Ogawa R , Riley MB , Nilsson KPR , Kraus A , Caughey B , Iliff JJ , Vera D , Esko JD , Sigurdson CJ

PLOS Pathology 2023

A case of prazosin in treatment of rapid eye movement sleep behavior disorder

Yeilim Cho, Jeffrey Iliff, Miranda Lim, Murray Raskind, Elaine Peskind

Journal of Clinical Sleep Medicine 2023

Emerging Perspectives on MRI Application in Multiple Sclerosis: Moving from Pathophysiology to Clinical Practice

Maria Assunta Rocca, Monica Margoni, Marco Battaglini, Arman Eshaghi, Jeffrey Iliff, Elisabetta Pagani, Paolo Preziosa, Loredana Storelli, Toshiaki Taoka, Paola Valsasina, Massimo Filippi

Radiology 2023

The effect of aquaporin-4 mis-localization on Aβ deposition in mice

Taylor J Pedersen, Samantha A Keil, Warren Han, Marie X Wang, Jeffrey J Iliff

Neurobiology of Disease 2023

Quantification approaches for magnetic resonance imaging following intravenous gadolinium injection: A window into brain‐wide glymphatic function

Sutton B Richmond, Swati Rane, Moriah R Hanson, Mehmet Albayram, Jeffrey J Iliff, Dawn Kernagis, Jens T Rosenberg, Rachael D Seidler

European Journal of Neuroscience 2023

Mapping the lymphatic system across body scales and expertise domains: A report from the 2021 National Heart, Lung, and Blood Institute workshop at the Boston Lymphatic Symposium

Dhruv Singhal, Katy Börner, Elliot L Chaikof, Michael Detmar, Maija Hollmén, Jeffrey J Iliff, Maxim Itkin, Taija Makinen, Guillermo Oliver, Timothy P Padera, Ellen M Quardokus, Andrea J Radtke, Hiroo Suami, Griffin M Weber, Ilsa I Rovira, Selen C Muratoglu, Zorina S Galis

Frontiers in Physiology 2023

Locoregional CAR T cells for children with CNS tumors: clinical procedure and catheter safety

Nicholas A Vitanza, Rebecca Ronsley, Michelle Choe, Casey Henson, Mandy Breedt, Adriel Barrios-Anderson, Amy Wein, Christopher Brown, Adam Beebe, Ada Kong, Danielle Kirkey, Brittany M Lee, Sarah ES Leary, Erin E Crotty, Corrine Hoeppner, Susan Holtzclaw, Ashley L Wilson, Joshua A Gustafson, Jessica B Foster, Jeffrey J Iliff, Hannah E Goldstein, Samuel R Browd, Amy Lee, Jeffrey G Ojemann, Navin Pinto, Juliane Gust, Rebecca A Gardner, Michael C Jensen, Jason S Hauptman, Julie R Park

Neoplasia 2023

The glymphatic system: Current understanding and modeling

Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal KA, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Kelley DH, Nedergaard M.

iScience 2022

Dynamic infrared imaging of cerebrospinal fluid tracer influx into the brain

Samantha A. Keil, Molly Braun, Ryan O'Boyle, Mathew Sevao, Taylor Pedersen, Sanjana Agarwal, Deidre Jansson, Jeffrey J. Illiff

Neurophotonics 2022

Longitudinal MRI-visible perivascular space (PVS) changes with long-duration spaceflight

Kathleen E. Hupfeld, Sutton B. Richmond, Heather R. McGregor, Daniel L. Schwartz, Madison Luther, Nichole E. Beltran, Igor S. Kofman, Yiri E. De Dios, Roy F. Riascos, Scott J. Wood, Jacob J. Bloomberg, Ajitkumar P. Mulavara, Lisa Silbert, Jeffrey J. Iliff, Rachael D. Seidler, Juan Piantino

Scientific Reports 2022

Markers of cerebrovascular injury, inflammation, and plasma lipids are associated with Alzheimer’s disease cerebrospinal fluid biomarkers in cognitively normal persons

Deidre Jansson, Marie Wang, Ronald Thomas, Michelle Erickson, Elaine Peskind, Ge Li, Jeffrey Iliff

Journal of Alzheimer’s Disease 2022

Impaired glymphatic function and pulsation alterations in a mouse model of vascular cognitive impairment

Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey Iliff, Karen Horsburgh

Frontiers in Aging Neuroscience 2022

Quantitative analysis of macroscopic solute transport in the murine brain

Lori A Ray, Martin Pike, Mathew Simon, Jeffrey J Iliff, Jeffrey J Heys

Fluid and Barriers of the CNS 2021

Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis

Mootaz Salman, Philip Kitchen, Andrea Halsey, Marie Wang, Susanna Tornroth-Horsefield, Alex Conner, Jerome Badaut, Jeffrey Iliff, Roslyn Bill

Brain 2021

Aquaporin-4 and glymphatic flow have central roles in brain fluid homeostasis.

Mootaz Salman, Philip Kitchen, Jeffrey Iliff, Roslyn Bill

Nature Reviews Neuroscience 2021

Role of endothelium-pericyte signaling in capillary blood flow response to neuronal activity.

Wenri Zhang, Catherine Davis, Douglas Zeppenfeld, Kirsti Golgotiu, Marie Wang, Mariya Haveliwala, Daniel Hong, Yuandong Li, Ruikang Wang, Jeffrey Iliff, Nabil Alkayed.

Journal of Cerebral Blood Flow and Metabolism 2021

Link between mild traumatic brain injury, poor sleep, and MRI-visible perivascular spaces in Veterans.

Juan Piantino, Daniel Schwartz, Madison Luther, Craig Newgard, Lisa Silbert, Murray Raskind, Kathleen Pagulayan, Natalia Kleinhans, Jeffrey Iliff, Elaine Peskind.

Journal of Neurotrauma 2021

Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival

Cymon N Kersch, Cheryl J Claunch, Prakash Ambady, Elmar Bucher, Daniel L Schwartz, Ramon F Barajas Jr, Jeffrey J Iliff, Tyler Risom, Laura Heiser, Leslie L Muldoon, James E Korkola, Joe W Gray, Edward A Neuwelt

Neuro-Oncology Advances 2020

Structural and functional conservation of non-lumenized lymphatic endothelial cells in the mammalian leptomeninges

Shannon Shibata-Germanos, James R. Goodman, Alan Grieg, Chintan A. Trivedi, Bridget C. Benson, Sandrine C. Foti, Ana Faro, Raphael F. P. Castellan, Rosa Maria Correra, Melissa Barber, Christiana Ruhrberg, Roy O. Weller, Tammaryn Lashley, Jeffrey J. Iliff, Thomas A. Hawkins, Jason Rihel

Acta Neuropathologica 2020

Vasomotor influences on glymphatic-lymphatic coupling and solute trafficking in the central nervous system

James Goodman and Jeffrey Iliff

Journal of Cerebral Blood Flow and Metabolism 2020

CrossTalk Proposal: The glymphatic system supports convective exchange of cerebrospinal fluid and brain interstitial fluid that is mediated by perivascular aquaporin-4

Jeffrey Iliff and Matthew Simon

Journal of Physiology 2019

CrossTalk opposing view: Going against the flow: interstitial solute transport in brain is diffusive and aquaporin‐4 independent (Smith and Verkman)

Rebuttal from Matthew Simon and Jeffrey Iliff

Rebuttal from Alex J. Smith and Alan S. Verkman

Sleep as a Therapeutic Target in the Aging Brain

Thierno Madjou Bah, James Goodman, Jeffrey J. Iliff

Neurotherapeutics 2019

Linking Traumatic Brain Injury, Sleep Disruption and Post-Traumatic Headache: a Potential Role for Glymphatic Pathway Dysfunction

Juan Piantino, Miranda M Lim, Craig D. Newgard, Jeffrey J. Iliff

Current Pain and Headache Reports 2019

In response to “Is solute movement within the extracellular spaces of brain gray matter brought about primarily by diffusion or flow?”

Lori Rey, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis

Carmen Methner, Anusha Mishra, Kirsti Golgotiu, Yuandong Li, Wei Wei, N. David Yanez, Berislav Zlokovic, Ruikang K. Wang, Nabil J. Alkayed, Sanjiv Kaul, Jeffrey J. Iliff

American Journal of Physiology: Heart and Circulation Physiology 2019

When the air hits your brain: decreased arterial pulsatility after craniectomy leading to impaired glymphatic flow

Benjamin A. Plog, Nanhong Lou, Clifford A. Pierre, Alex Cove, H. Mark Kenney, Emi Hitomi, Hongyi Kang, Jeffrey J. Iliff, Douglas M. Zeppenfeld, Maiken Nedergaard, G. Edward Vates

Journal of Neurosurgery 2019

Analysis of convective and diffusive transport in the brain interstitium

Lori Ray, Jeffrey Iliff, Jeffrey Heys

Fluid and Barriers of the CNS 2019

Transcriptional network analysis of human astrocytic endfoot genes reveals region-specific associations with dementia status and tau pathology

Matthew J. Simon, Marie X. Wang, Charles F. Murchison, Natalie E. Roese, Erin L. Boespflug, Randall L. Woltjer, Jeffrey J. Iliff

Scientific Reports 2018

Targeted Assessment of Enlargement of the Perivascular Space in Alzheimer’s Disease and Vascular Dementia Subtypes Implicates Astroglial Involvement Specific to Alzheimer’s Disease

Erin L. Boespflug, Matthew Simon, Emmalyn Leonard, Marjorie Grafe, Randall Woltjer, Lisa Silbert, Jeffrey Kaye, Jeffrey Iliff

Journal of Alzheimer’s Disease 2018

Characterization of dural sinus-associated lymphatic vasculature in human Alzheimer’s dementia subjects

James R. Goodman, Zachariah O. Adham, Randall L. Woltjer, Amanda W. Lund. Jeffrey J. Iliff

Brain, Behavior and Immunity 2018

The Emerging Relationship Between Interstitial Fluid–Cerebrospinal Fluid Exchange, Amyloid-β, and Sleep

Erin Boespflug and Jeffrey Iliff

Biological Psychiatry 2018

The effects of noncoding aquaporin-4 single-nucleotide polymorphisms on cognition and functional progression of Alzheimer's disease

Kevin G. Burfeind, Charles F. Murchison, Shawn K. Westaway, Matthew J. Simon, Deniz Erten-Lyons, Jeffrey A. Kaye, Joseph F. Quinn, Jeffrey J. Iliff

Alzheimer's & Dementia: Translational Research & Clinical Interventions 2017

MR Imaging–based Multimodal Autoidentification of Perivascular Spaces (mMAPS): Automated Morphologic Segmentation of Enlarged Perivascular Spaces at Clinical Field Strength

Erin L. Boespflug , Daniel L. Schwartz, David Lahna, Jeffrey Pollock, Jeffrey J. Iliff, Jeffrey A. Kaye, William Rooney, Lisa C. Silbert

Neurology 2018

A transcriptome‐based assessment of the astrocytic dystrophin‐associated complex in the developing human brain

Matthew J. Simon, Charles Murchison, Jeffrey J. Iliff

Journal of Neuroscience Research 2017

Focal Solute Trapping and Global Glymphatic Pathway Impairment in a Murine Model of Multiple Microinfarcts

Minghuan Wang, Fengfei Ding, SaiYue Deng, Xuequn Guo, Wei Wang, Jeffrey J. Iliff and Maiken Nedergaard

Journal of Neuroscience 2017

Association of Perivascular Localization of Aquaporin-4 With Cognition and Alzheimer Disease in Aging Brains

Douglas M. Zeppenfeld, Matthew Simon, J. Douglas Haswell, Daryl D’Abreo, Charles Murchison, Joseph F. Quinn, Marjorie R. Grafe, Randall L. Woltjer, Jeffrey Kaye, Jeffrey J. Iliff

JAMA Neurology 2017

Methamphetamine induces the release of endothelin

Jeong‐Woo Seo, Susan M. Jones, Trisha A. Hostetter, Jeffrey J. Iliff, G. Alexander West

Journal of Neuroscience Research 2016

Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease

Matthew J. Simon and Jeffrey J. Iliff

Biochim Biophys Acta 2016

Our recently published abstracts

Investigating the Behavioral and Biological Effects of Chronic Alcohol Use in a Mouse Model of Blast-Induced Mild Traumatic Brain Injury. Makenzie Patarino, Mathew Sevao, Tami Wolden-Hanson, Garth Terry, Bryan Schuessler, Alexandria Murry, Samantha Keil, Sam Golden, Jeffrey Iliff, Abbie Schindler. Journal of Pharmacology and Experimental Therapeutics 389 (S3). 2024.

ASSOCIATION OF RAPID EYE MOVEMENT SLEEP AND APOE PROTEOTYPE TO COGNITIVE PERFORMANCE IN OLDER ADULTS. Edward Hammel, Mitchell Roberts, Erica Sappington, Paul Dagum, Jeffrey Iliff, Swati Rane Levendovszky, Jeff Lowenkron, Carla VandeWeerd. Innovation in Aging 7 (Supplement_1), 994-994. 2023.

ASSOCIATIONS BETWEEN THE GERIATRIC DEPRESSION SCALE AND APNEA-HYPOPNEA INDEX IN OLDER ADULTS. Alyssa Persad, Edward Hammel, Mitchell Roberts, Erica Sappington, Paul Dagum, Jeffrey Iliff, Swati Rane Levendovszky, Carla VandeWeerd. Innovation in Aging 7 (Supplement_1), 995-995. 2023.

EXAMINING THE PREVALENCE OF UNDIAGNOSED SLEEP APNEA AND ITS ASSOCIATION WITH BLOOD BIOMARKERS FOR ALZHEIMER’S. Mitchell Roberts, Erica Sappington, Michael Jaffee, Jeff Lowenkron, Paul Dagum, Jeffrey Iliff, Swati Rane Levendovszky, Carla VandeWeerd. Innovation in Aging 7 (Suppl 1), 1033. 2023.

MALE AND FEMALE PERSPECTIVES: EXPLORING THE USE OF PASSIVE BRAIN HEALTH TECHNOLOGY TO MEASURE GLYMPHATIC FUNCTION. Cyriah Carey, Erica Sappington, Mitchell Roberts, Paul Dagum, Jeffrey Iliff, Swati Rane Levendovszky, Michael Jaffee, Carla VandeWeerd. Innovation in Aging 7 (Supplement_1), 1077-1077 2023.

Executive function performance depends on hypertension in individuals with sub‐threshold total Hachinski score. Jaqueline A Flores, Tejaswi D Sudhakar, Taylor J Pedersen, Cole E Anderson, Elaine R Peskind, Ge Li, Jeffrey J Iliff, Swati Rane, Alzheimer’s Disease Neuroimaging Initiative (ADNI). Alzheimer's & Dementia 19, e076838. 2023.

Present and past hypertension in ADNI3 individuals with sub‐threshold total Hachinski ischemic score reflect greater hyperintensity burden irrespective of cognitive status. Taylor J Pedersen, Jaqueline A Flores, Tejaswi D Sudhakar, Cole E Anderson, Elaine R Peskind, Ge Li, Jeffrey J Iliff, Swati Rane, Alzheimer’s Disease Neuroimaging Initiative. Alzheimer's & Dementia 19, e077285. 2023.

Glymphatic function maintains sleep‐sensitive cognitive performance and predicts overnight changes in plasma amyloid β in humans. Shilpa Balkrishnan, Laurent Giovangrandi, Carla Vanderweerd, Tarandeep Singh, Michael Jaffe, Jeffrey Lowenkron, Miranda Lim, Jeffrey J Iliff, Paul Dagum. Alzheimer's & Dementia 19, e083169. 2023.

Longitudinal sleep instability predicts cognitive decline and is associated with increased MRI‐visible perivascular space burden. Samantha A Keil, Abigail G Schindler, Juan Piantino, Miranda Lim, Sherry L Willis, Jeffrey J Iliff. Alzheimer's & Dementia 19, e075033. 2023.

The role of aquaporin‐4 localization in glymphatic impairment and tau aggregation in post‐traumatic neurodegeneration. Molly Braun, Mathew Sevao, Elizabeth Gino, Samantha A Keil, Taylor J Pedersen, Sanjana Agarwal, Jay Jang, Justyna Swierz, Keith Sanderson, Deidre Jansson, Jeffrey J Iliff. Alzheimer's & Dementia 19, e080496. 2023.

The effect of aquaporin‐4 mis‐localization on Aβ pathology in mice. Taylor J Pedersen, Samantha A Keil, Warren Han, Marie X Wang, Jeffrey J Iliff. Alzheimer's & Dementia 19, e077606. 2023.

CSF Alzheimer’s Disease Biomarker Changes in Veterans with Mild Traumatic Brain Injury. Ge Li, Jeffrey J Iliff, Jane Shofer, Cynthia L Mayer, James Meabon, Henrik Zetterberg, Kaj Blennow, Elaine R Peskind. Alzheimer's & Dementia 19, e073350. 2023.

Noninvasive and remote measurement of sleep‐active glymphatic function in the human brain by dynamic impedance spectro‐tomography. Jeffrey J Iliff, Swati Rane Levendovszky, Carla Vanderweerd, Michael Jaffe, Jeffrey Lowenkron, Tarandeep Singh, Laurent Giovangrandi, Miranda Lim, Paul Dagum. Alzheimer's & Dementia 19, e083160. 2023.

Neutrophil extracellular traps in amyloid pathology & glymphatic impairment. Molly Braun, Mathew Sevao, Elizabeth Gino, Samantha A Keil, Taylor J Pedersen, Jay Jang, Justyna Swierz, Keith Sanderson, Deidre Jansson, Jeffrey J Iliff. Alzheimer's & Dementia 19, e072154. 2023.

Combined DTI and NODDI Scalars Improves Understanding of At‐Risk Tissue in and Around White Matter Hyperintensities. Tejaswi D Sudhakar, Cole E Anderson, Elaine R Peskind, Ge Li, Jeffrey J Iliff, Swati Rane Levendovszky. Alzheimer's & Dementia 19, e082408. 2023.

Fluid Biomarkers for Neurobehavioral Dysregulation in Former American Football Players. Suzan van Amerongen, Surya V Pulukuri, Yorghos Tripodis, Charles B Bernick, Yonas E Geda, Jennifer Wethe, Douglas I Katz, Michael L Alosco, Jesse B Mez, Joseph N Palmisano, Fatima Tuz‐Zahra, Charles Adler, Laura Balcer, Nicholas J Ashton, Kaj Blennow, Jeffrey J Iliff, Ge Li, Henrik Zetterberg, Elaine R Peskind, Eric M Reiman, Martha E Shenton, Jeffrey L Cummings, Robert A Stern. Alzheimer's & Dementia 19, e077858. 2023.

Comparison of IVIM MRI measures of brain fluid transport against contrast‐enhanced MRI in the setting of sleep deprivation. Swati Rane Levendovszky, Carla Vanderweerd, Mitchell Roberts, Tarandeep Singh, Alejandro Corbellini, Michael Jaffe, Jeffrey Lowenkron, Juan Piantino, Miranda Lim, Paul Dagum, Jeffrey J Iliff. Alzheimer's & Dementia 19, e082762. 2023.

IMMU-26. MRNA CAR T CELL TRAFFICKING FOLLOWING INTRA-VENTRICULAR ADMINISTRATION IN PRECLINICAL MODELS OF DIFFUSE MIDLINE GLIOMA. Zein Al-atrache, Olivia Mcmanus, Kyra Harvey, Conor Dickson, Luke Patterson, Ezra Beaubien, Cullen Wilson, Sreehita Hajeebu, Samantha Keil, Molly Braun, Michael Meechan, Nicholas Vitanza, Jeffrey Iliff, Peter Madsen, Jessica Foster. Neuro-Oncology 25 (Suppl 5), v147. 2023.

Alcohol after injury: Uncovering the synergistic effects of chronic alcohol use after blast-induced mTBI. Makenzie Patarino, Samantha Keil, Alexandria Murry, Mathew Sevao, Tami Wolden-Hanson, Garth Terry, Sam Golden, Jeffrey Iliff, Abbie Schindler. Brain, Behavior, and Immunity 114, 46-47. 2023.

Development and validation of low-level Transcranial Electrical Stimulation to enhance slow oscillations during human NREM sleep. Miranda Lim, Christina Reynolds, Noah Milman, Jonathan Elliott, Carolyn Tinsley, Swati Levendovzsky, Jeffrey Iliff, Phan Luu, Dawn Kernagis, Don Tucker. Sleep 46 (Supplement_1), A119-A119. 2023.

Longitudinal Sleep Instability and Depression: Finding From the Seattle Longitudinal Study. Y Cho, S Keil, J Iliff. A36. SLEEP-RELATED HEALTH SERVICES RESEARCH, A1432-A1432. 2023.

THE ROLE OF PERIVASCULAR AQUAPORIN-4 LOCALIZATION IN POST-TRAUMATIC NEURODEGENERATION. Elizabeth Gino, Molly Braun, Mathew Sevao, Sam Keil, Sanjana Agarwal, Taylor Pederson, Ron Vered, Jeffrey Iliff. JOURNAL OF NEUROTRAUMA 39 (11-12), A65-A65. 2022.

ALTERED AQUAPORIN-4 EXPRESSION AND DELAYED GLYMPHATIC IMPAIRMENT FOLLOWING BLAST INJURY. Molly Braun, Elizabeth Gino, Mathew Sevao, Sam Keil, Marie Wang, Taylor Pederson, Sanjana Agarwal, Mariya Haveliwala, Elaine Peskind, Harker Rhodes, Daniel Perl, David Cook, Abigail Schindler, Jeffrey Iliff. JOURNAL OF NEUROTRAUMA 39 (11-12), A38-A38. 2022.

LONGITUDINAL SLEEP INSTABILITY CONTRIBUTES TO COGNITIVE DECLINE AND ALZHEIMER'S PATHOLOGY: FINDINGS FROM THE SEATTLE LONGITUDINAL STUDY. Samantha Keil, Abigail Schindler, Marie Wang, Miranda Lim, Juan Piantino, Jon Elliott, Maddi Werhane, Ronald Thomas, Jeffrey Iliff. SLEEP 45, A283-A283. 2022.

Non-Invasive Quantification of Human Brain Lactate Concentrations Across Sleep-Wake Cycles. Selda Yildiz, Miranda Lim, Manoj Sammi, Katherine Powers, Charles Murchison, Jeffrey Iliff, William Rooney. Sleep 44, A101-A102. 2021.

Lightning Presentation Round: Protein Clearance. Jeffrey J Iliff, Caitlin S Latimer. AAIC Neuroscience Next. 2020.

Neuro-Oncology Advances. Cymon N Kersch, Cheryl J Claunch, Prakash Ambady, Elmar Bucher, Daniel L Schwartz, Ramon F Barajas Jr, Jeffrey J Iliff, Tyler Risom, Laura Heiser, Leslie L Muldoon, James E Korkola, Joe W Gray, Edward A Neuwelt.

TRANSCRIPTIONAL SIGNATURES IN HISTOLOGIC STRUCTURES WITHIN GLIOBLASTOMA TUMORS MAY PREDICT PERSONALIZED TREATMENT SENSITIVITY AND SURVIVAL. Cymon Kersch, Cheryl Claunch, Prakash Ambady, Elmar Bucher, Daniel Schwartz, Ramon Barajas, Jeffrey Iliff, Laura Heiser, Leslie Muldoon, Edward Neuwelt. Neuro-Oncology 21 (Supplement_6), vi157-vi157. 2019.

Vascular Biology and Microcirculation: Pericyte constriction underlies capillary derecruitment during hyperemia in the setting of arterial stenosis. Carmen Methner, Anusha Mishra, Kirsti Golgotiu, Yuandong Li, Wei Wei, N David Yanez, Berislav Zlokovic, Ruikang K Wang, Nabil J Alkayed, Sanjiv Kaul, Jeffrey J Iliff. American Journal of Physiology-Heart and Circulatory Physiology 317 (2), H255. 2019.

CHARACTERISING THE ASTROCYTIC PROFILE OF DYSTROBREVIN IN THE BRAIN DURING ALZHEIMER'S DISEASE. Ozama Ismail, Marie X Wang, Jeffrey J Iliff. Alzheimer's & Dementia 15, P1002-P1003. 2019.

Glymphatic and meningeal lymphatic function in health and disease. JJ Iliff. JOURNAL OF NEUROIMMUNE PHARMACOLOGY 14 (2), 337-337. 2019.